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Proceedings of the Estonian Academy of Sciences

ISSN 1736-7530 (electronic)   ISSN 1736-6046 (print)
Formerly: Proceedings of the Estonian Academy of Sciences, series Physics & Mathematics and  Chemistry
Published since 1952

Proceedings of the Estonian Academy of Sciences

ISSN 1736-7530 (electronic)   ISSN 1736-6046 (print)
Formerly: Proceedings of the Estonian Academy of Sciences, series Physics & Mathematics and  Chemistry
Published since 1952
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Potassium iodide catalysis in the alkylation of protected hydrazines; pp. 10–17

(Full article in PDF format) https://doi.org/10.3176/proc.2017.1.03


Authors

Anton Mastitski, Aleksander Abramov, Anneli Kruve, Jaak Järv

Abstract

Potassium iodide catalysis was applied for the synthesis of protected benzylhydrazines and hydrazinoacetic acid esters by the alkylation of protected hydrazines. Benzylic halogenides and halogenoacetic acid esters were employed as alkylating agents. In these syntheses the reactive alkyl iodide molecules were generated in situ from less reactive halogenides, which significantly accelerated the alkylation reaction. The effectiveness of potassium iodide catalysis was proved by experiments performed under the same conditions in the absence of this salt.

Keywords

alkylation, aza-tyrosine, aza-tryptophan precursors, aza-amino acid precursors, hydrazine derivatives, monoprotected hydrazine alkylation, protecting groups, bromination, potassium iodide catalysis.

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Current Issue: Vol. 68, Issue 3, 2019




Publishing schedule:
No. 1: 20 March
No. 2: 20 June
No. 3: 20 September
No. 4: 20 December