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Proceedings of the Estonian Academy of Sciences

ISSN 1736-7530 (electronic)   ISSN 1736-6046 (print)
Formerly: Proceedings of the Estonian Academy of Sciences, series Physics & Mathematics and  Chemistry
Published since 1952

Proceedings of the Estonian Academy of Sciences

ISSN 1736-7530 (electronic)   ISSN 1736-6046 (print)
Formerly: Proceedings of the Estonian Academy of Sciences, series Physics & Mathematics and  Chemistry
Published since 1952
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Synthesis of the Fmoc-aza-Arg(Boc)2 precursor via hydrazine alkylation; pp. 438–443

(Full article in PDF format) doi: 10.3176/proc.2014.4.09


Authors

Anton Mastitski, Ksenija Kisseljova, Jaak Järv

Abstract

The aza-arginine precursor Fmoc-aza-Arg(Boc)2 was synthesized starting from mono-protected hydrazines via an aza-ornithine precursor. This reaction path is shorter and more efficient than the reductive alkylation reaction.

Keywords

aza-arginine precursor, hydrazine derivatives, alkylation, guanylation, protecting groups.

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Current Issue: Vol. 68, Issue 3, 2019




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